- 廖建
- 电子邮件：jliao@cib.ac.cn
- 职 称：研究员
- 学 历：博士研究生
- 通讯地址：四川省成都市天府新区群贤南街23号
- 邮 编：610213
个人简历
博士，研究员，博士生导师。1994年毕业于上海交通大学应用化学系， 2002年在中科院成都有机所获理学博士学位。2006年2月后被聘为中科院成都有机所研究员，任不对称合成与手性技术四川省重点实验室副主任，所学位评定委员会委员。2008年入选中国科学院“西部之光”人才计划，2009年入选四川省学术和技术带头人后备人选。2010年9月调入中科院成都生物所。现任天然产物研究中心主任、所学术委员会委员、中国科学院大学专业学位培养指导委员会委员、中科院四川转化医学研究医院学术委员会、四川省第二届药品安全专家委员会委员。主要从事手性配体设计、不对称催化以及天然产物合成研究。在国际核心学术刊物（包括J. Am. Chem. Soc., Angew. Chem. Int. Ed., Chem. Sci., Org. Lett.等）上发表学术论著40余篇，获准和申请了发明专利近10项。?
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研究方向
手性配体设计与不对称催化反应方法学、天然产物合成方法学、药物及关键中间体合成?
获奖及荣誉
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承担科研项目情况
国家自然科学基金委面上项目?
参加国家973计划子项目?
中科院“西部之光”人才计划?
中科院STS项目?
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代表论著
1.????????? X. Wang, B. Wang, X. Yin, W. Yu, Y. Liao, J. Ye, M. Wang, L. Hu, J. Liao* “Palladium Catalyzed Enantioselective Thiocarbonylation of Styrenes” Angew. Chem. Int. Ed. 2019, 58, in press, doi: 10.1002/anie.201905905 (hot paper)?
2.????????? B. Wang, X. Wang, X. Yin, W. Yu, Y. Liao, J. Ye, M. Wang, J. Liao* “Cu-Catalyzed SN2' Substitution of Propargylic Phosphates with Vinylarene-derived Chiral Nucleophiles: Synthesis of Chiral Allenes” Org. Lett. 2019, 21, 3913.?
3.????????? T. Jia, M. Wang, J. Liao* “Chiral Sulfoxide Ligands in Asymmetric Catalysis” Top Curr Chem 2019, 377, doi: 10.1007/s41061-019-0232-9.?
4.????????? B. Chen, P. Cao, Y. Liao, M. Wang, J. Liao* “Enantioselective Copper-Catalyzed Methylboration of Alkenes” Org. Lett. 2018, 20, 1346. ?
5.????????? T. Jia, P. Cao*, J. Liao* “Enantioselective synthesis of gem-diarylalkanes by transition metal-catalyzed asymmetric arylations (TMCAAr)” Chem. Sci. 2018, 9, 546. ?
6.????????? B. Chen, P. Cao, X. Yin, Y. Liao, L. Jiang, J. Ye, M. Wang, and J. Liao* “Modular Synthesis of Enantioenriched 1,1,2-Triarylethanes by an Enantioselective Arylboration and Cross-Coupling Sequence” ACS Catal., 2017, 7, 2425. ?
7.????????? Y. Zhang, M. Wang, P. Cao, J. Liao* “Copper-catalyzed enantioselective aminoboration of styrenes with chiral sulfoxide phosphine ligand” Acta Chimica Sinica 2017, 75, 794. ?
8.????????? L. Jiang, P. Cao*, M. Wang, B. Chen, B. Wang, J. Liao* “Highly Diastereo- and Enantioselective Cu-Catalyzed Borylative Coupling of 1,3-Dienes and Aldimines” Angew. Chem. Int. Ed., 2016, 55, 13854. ?
9.????????? T. Yang, Y. Zhang, P. Cao, M. Wang, L. Li, D. Li*, J. Liao*, “Copper-catalyzed enantioselective conjugate addition of diethylzinc to acyclic enones with chiral sulfoxide–phosphine ligands” Tetrahedron, 2016, 72, 2707. ?
10.?????? T. Jia, P. Cao, B. Wang, Y. Lou, X. Yin, M. Wang, J. Liao* “A Cu/Pd Cooperative Catalysis for Enantioselective Allylboration of Alkenes” J. Am. Chem. Soc. 2015, 137, 13760 ( Highlighted by JACS Spots). ?
11.?????? Y. Lou, P. Cao, T. Jia, Y. Zhang, M. Wang, J. Liao* “Cu-Catalyzed Enantioselective 1,6-Boration of para-Quinone Methides and Efficient Transformation of gem-Diarylmethine Boronates to Triarylmethanes” Angew. Chem. Int. Ed. 2015, 54, 12134. ?
12.?????? T. Jia, P. Cao, D. Wang, Y. Lou, J. Liao* “Copper-Catalyzed Asymmetric Three-Component Borylstannation: Enantioselective Formation of C-Sn Bond” Chem. Eur. J. 2015, 21, 4918. ?
13.?????? Liyin Jiang, Tao Jia, Min Wang, Jian Liao, and Peng Cao* “Pd-Catalyzed Enantioselective Hydroalkoxylation of Alkoxyallenes with Phenol for Construction of Acyclic O,O-Acetals” Org. Lett., 2015, 17 ,1070.?
14.?????? D. Wang, P. Cao, B. Wang, T. Jia, Y. Lou, M. Wang, J. Liao* “Copper(I)-Catalyzed Asymmetric Pinacolboryl Addition of N-Boc-imines Using a Chiral Sulfoxide–Phosphine Ligand” Org. Lett., 2015, 17, 2420. ?
15.?????? J. Wang, B. wang, P. Cao, J. Liao* “Rhodium Catalyzed Asymmetric 1,4-Addition of Arylboronic Acids to , -Unsaturated -Keto Ester Using Chiral tert-Butanesulfinylphosphines Ligands” Tetrahedron Lett. 2014, 55, 3450. ?
16.?????? J. Wang, M. Wang, P. Cao, L. Jiang, G. Chen, J. Liao* “Rh-Catalyzed Asymmetric Arylation of , -Unsaturated -Ketoamides for the Construction of Nonracemic , -Diarylcarbonyls” Angew. Chem. Int. Ed. 2014, 53, 6673. (Highlighted by Synfacts, 2014, 1042) ?
17.?????? L. Du, P. Cao, J. Liao* “Bifunctional Ligand Promoted Pd-Catalyzed Asymmetric Allylic Etherification/Amination” Acta Chimica Sinica 2013, 71, 1239. ?
18.?????? L. Du, P. Cao, J. Xing, Y. Lou, L. Jiang, L. Li, J. Liao* “Hydrogen Bond Promoted Palladium Catalysis: Allylic Alkylation of Indoles with Unsymmetrical 1,3-Disubstituted Allyl Acetates Using Chiral Bis(sulfoxide) Phosphine Ligands” Angew. Chem. Int. Ed. 2013, 52, 4207. ?
19.?????? J. Gui, G. Chen, P. Cao, J. Liao* “Rh(I)-catalyzed asymmetric addition of arylboronic acids to NH isatins” Tetrahedron: Asymmetry 2012, 23,554. ?
20.?????? J. Xing, P. Cao, J. Liao* “Chiral SO/P hybrid ligands: an enantioselective switch in palladium-catalyzed asymmetric allylic etherifications” Tetrahedron: Asymmetry 2012, 23, 527. ?
21.?????? G. Chen, J. Gui, P. Cao, J. Liao* “Chiral sulfoxideeolefin ligands: tunable stereoselectivity in Rh-catalyzed asymmetric 1,4-additions” Tetrahedron 2012, 68, 3220. ?
22.?????? G. Chen, J. Xing, P. Cao, J. Liao* “Rh/chiral sulfinylphosphine catalyzed asymmetric 1,4-addition of arylboronic acids to chalcones” Tetrahedron 2012, 68, 5908. ?
23.?????? J. Xing, G. Chen, P. Cao, J. Liao* “Rhodium-Catalyzed Asymmetric Addition of Arylboronic Acids to Indolylnitroalkenes” Eur. J. Org. Chem. 2012, 1230. ?
24.?????? X. Zhang, G. Chen, P. Cao, J. Liu, J. Liao* “Rhodium-Catalyzed Michael Addition of Arylboronic Acids to 3-Alkylenyloxindoles: Asymmetric Synthesis of Functionalized Oxindoles” Tetrahedron Lett. 2012, 53, 438. ?
25.?????? G. Chen, J. Gui, L. Li, J. Liao* “Chiral Sulfoxide-Olefin Ligands: Completely Switchable Stereoselectivity in the Rh-Catalyzed Asymmetric Conjugate Additions” Angew. Chem. Int. Ed. 2011, 50, 7681 (hot paper, Highlighted by Synfacts, 2011, 1193). ?
26.?????? F. Han, G. Chen, X. Zhang, J. Liao* “Chiral Hetero-Disulfoxide Ligands in Rhodium-Catalyzed Asymmetric 1,4-Addition of Arylboronic Acids to Chromenones” Eur. J. Org. Chem. 2011, 2928. ?
27.?????? F. Lang, G. Chen, L. Li, J. Xing, F. Han, L. Cun, J. Liao* “Rhodium-Catalyzed Highly Enantioselective Addition of Arylboronic Acids to 2-Nitrostyrenes by tert-Butanesulfinylphosphine Ligand” Chem. Eur. J. 2011, 5242 (Highlighted by Synfacts, 2011, 882). ?
28.?????? J. Liu, G. Chen, J. Xing, J. Liao* “tert-Butanesulfinylthioether ligands: synthesis and application in palladium-catalyzed asymmetric allylic alkylation” Tetrahedron: Asymmetry 2011, 22, 575. ?
29.?????? X. Zhang, J. Chen, F. Han, L. Cun, J. Liao* “Rhodium-Catalyzed Enantioselective Conjugate Addition of Sodium Tetraaryl-borates to 2,3-Dihydro-4-Pyridones and 4-Quinolones by Using (R,R)-1,2-bis(tert-butylsulfinyl)benzene as Ligand” Eur. J. Org. Chem. 2011, 1443. ?
30.?????? F. Han, J. Chen, X. Zhang, J. Liu, L. Cun, J. Zhu, J. Deng, J. Liao* “Rhodium-catalyzed asymmetric addition of arylboronic acids to -phthalimido-substituted- , -unsaturated carboxylic acid esters: an approach to -amino acids” Tetrahedron Lett. 2011, 52, 830. ?
31.?????? J. Chen, J. Chen, F. Lang, X. Zhang, L. Cun, J. Zhu, J. Deng, J, Liao* “A C2-Symmetric Chiral Bis-Sulfoxide Ligand in Rhodium-Catalyzed Reaction: Asymmetric 1, 4- Addition of Sodium Tetraarylborates to Chromenones” J. Am. Chem. Soc. 2010, 132，4552. (Highlighted by Synfacts, 2010, 790.) ?
32.?????? F. Lang, D. Li, J. Chen, J. Chen, L. Li, L. Cun, J. Zhu, J. Deng, J. Liao* “tert-Butanesulfinylphosphines: Simple Chiral Ligands in Rhodium-Catalyzed Asymmetric Addition of Arylboronic Acid to Electron-Deficient olefins” Adv. Synth & Catal. 2010, 352, 843. ( Highlighted by Synfacts, 2010, 667) ?
33.?????? P. Wang, J. Chen, L. Cun, J. Deng, J. Zhu, J. Liao* “Aryl tert-Butyl Sulfoxide-Promoted Highly Enantioselective Addition of Allyltrichlorosilane to Aldehydes”Org. Biomol. Chem., 2009, 7, 3741. ?
34.?????? X. Guan, Zh. Liu, H. Huang, L. Yang, J. Liao*, W. Hu* “Novel C–S Bond Formation Through a’,b-Elimination of tert-Butyl Sulfoxonium Ylides: A Facile Approach to Chiral Sulfoxides” Synlett. 2009, 2183. ?
35.?????? J. Chen, F. Lang, D. Li, L. Cun, J. Zhu, J. Deng, J. Liao* “Palladium-catalyzed asymmetric allylic nucleophilic substitution reactions using chiral tert-butanesulfinylphosphine ligands” Tetrahedron: Asymmetry 2009, 20, 1953.(Highlighted by Synfact, 2009, 1374). ?
36.?????? 廖建，邓金根 《不对称催化新概念与新方法》，（丁奎岭、范青华主编）第20章：不对称催化—从学术研究到工业应用（典型案例分析）。2009年，化学工业出版社。?
37.?????? D. Li, J. Deng, J. Zhu, J. Liao* “Synthesis of 3,3'-Substituted Biphenyl and Binaphthyl-based Phosphoramidite Ligands” Chin. Synth. Chem. 2008, 16, 656. ?
38.?????? J. Chen, D. Li, H. Ma, L. Cun, J. Zhu, J. Deng, J. Liao* “Catalytic asymmetric synthesis of -branched chiral amines using a novel chiral tert-butanesulfinylphosphine ligand”Tetrahedron Lett. 2008. 49. 6921. ?
39.?????? J. Liao; Qing Wang* “Ruthenium-Catalyzed Knoevenagel Condensation: A New Route toward Cyano-Substituted Poly(p-phenylenevinylene)s” Macromolecules 2004, 37, 7061. ?
40.?????? J. Liao; X. X. Sun; X. Cui; K. B. Yu; J. Zhu; J. G. Deng* “Facile optical resolution of tert-butanethiosulfinate by molecular complexation with (R)-BINOL and study of chiral discrimination of the diastereomeric complexes” Chem. Eur. J. 2003, 9, 2611.?
41.?????? J. Liao; X. H. Peng; J. H. Zhang; K. B. Yu; X. Cui; J. Zhu; J. G. Deng* “Facile resolution of racemic terbutaline and a study of molecular recognition through chiral supramolecules based on enantiodifferentiating self-assembly” Org. & Biomol. Chem. 2003, 1, 1080.?
